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Priya · 6/13/2026

Semaglutide vs tirzepatide — the trial data, plainly

Plain-English version: both have large randomized trials (STEP / SURMOUNT / SURPASS). Tirzepatide is a dual agonist and tended to show larger average weight change in head-to-head-ish comparisons. Read the primary trials, not the threads.

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