DSIP (Delta Sleep-Inducing Peptide) is a naturally occurring nine-amino-acid peptide first isolated in the 1970s from the cerebral blood of sleeping rabbits. It has been studied mainly in animals for effects on sleep, stress, and hormone release. It is a research chemical and is not an approved medicine.

What is DSIP studied for?

Most DSIP research is older preclinical (animal) work plus a small number of human sleep studies from the 1980s. Reported research themes include sleep regulation, stress responses, and possible roles in opioid-withdrawal symptoms. None of this establishes that DSIP is safe or effective in humans.

Is DSIP FDA-approved?

No. DSIP is not approved by the U.S. FDA for any use. Under the name emideltide it is on the agenda of the FDA's Pharmacy Compounding Advisory Committee (a meeting scheduled for July 2026) to discuss whether it should be added to the Section 503A list of bulk substances allowed in pharmacy compounding. That is an advisory process, not drug approval, and as of mid-2026 it remains a research compound, not an approved drug. It is sold only for research use, not for human consumption.

DSIP is not an approved drug or dietary supplement in the United States, so it cannot legally be marketed for human consumption. It is generally sold only as a research chemical. Anti-doping rules and laws differ by country and sport, so verify local regulations and consult a licensed professional.

What are the reported side effects of DSIP?

Human safety data are very limited because rigorous modern trials are lacking. Older human studies reported few effects, with occasional transient headache, nausea, or dizziness. Long-term safety is unknown, and research-chemical purity is not guaranteed. Speak with a licensed clinician before considering it.

Does DSIP actually work for sleep?

The evidence is weak and dated. A few small 1980s human studies suggested modest improvements in people with disturbed sleep, while healthy sleepers saw little effect. There are no adequately powered, modern, placebo-controlled trials, so DSIP is not a proven sleep treatment.

There is no validated human dose. Older studies used amounts that do not translate into safe human guidance. This page does not provide dosing instructions; any decision about dose, route, or frequency is a medical decision that belongs with a licensed clinician who knows your history.

Sleep · Dosage

DSIP dosage

DSIP comes in 5 mg vials. Pick your vial to see exactly how much bacteriostatic water to add and how many insulin units to draw. Reconstitution math and unit conversions for the 5 mg vial. DSIP has very limited human data and no validated dose; the usage pattern shown is community-reported and anecdotal.

5mg

At 2 mL water: 2.5 mg/mL
Per unit: 25 mcg

See the 5 mg card

Calculate for your vial

Enter the mg on your DSIP vial, the bacteriostatic water you added, and your target dose — it works out the exact units to draw on a U-100 insulin syringe, for whatever you personally have.

Reconstitution Calculator

Units to draw (U-100)10units

Volume to draw0.1mL

Concentration2.5mg/mL

Per insulin unit25mcg

Doses per vial20doses

Check the decimal. A misplaced decimal point here is a 10× dosing error. Re-read every number, and confirm your dose with a licensed clinician before you draw.

Educational only — not a dosing recommendation. This tool does the measurement math; it does not tell you what to take. On a U-100 insulin syringe, 100 units = 1 mL.

Reconstitution figures are deterministic measurement math. WikiPeps is a community reference and sells injection supplies only — never peptides. Nothing here is medical advice.