Kisspeptin is a naturally occurring signaling peptide encoded by the KISS1 gene. It acts on the KISS1R (GPR54) receptor on GnRH neurons in the hypothalamus and is a key upstream regulator of the body's reproductive hormone system. Kisspeptin-10 (KP-10), also called metastin, is the short, biologically active fragment most often used in research. It is investigational and not an FDA-approved drug.

What is kisspeptin studied for?

In human research it has been studied mainly as a tool and potential therapy for reproductive conditions — stimulating reproductive hormone release, supporting egg maturation in IVF, and exploring functional hypothalamic amenorrhea and certain forms of low sexual desire. These are active research areas, not proven, approved treatments.

Is kisspeptin FDA-approved or legal?

Kisspeptin is not FDA-approved for any use. It has been used under research authorizations in hospital and clinical-trial settings. In 2024 an FDA advisory committee reviewed kisspeptin-10 for the 503A compounding bulks list, and the FDA proposed not adding it, citing limited physicochemical characterization, gaps in immunogenicity data, and insufficient evidence of effectiveness. Material sold for 'research use only' is not an approved medicine and is not a substitute for clinician-supervised care.

How does kisspeptin work?

Kisspeptin binds the KISS1R (GPR54) receptor on GnRH neurons in the hypothalamus, prompting them to release GnRH (gonadotropin-releasing hormone). GnRH then signals the pituitary to release LH and FSH, which act on the gonads. In effect, kisspeptin sits upstream of the whole hypothalamic-pituitary-gonadal axis.

What is kisspeptin's half-life?

Kisspeptin-10 has a very short half-life in humans — reported at roughly 4 minutes — because it is rapidly broken down by enzymes in the blood and filtered by the kidneys. The parent peptide is largely cleared within about 30 minutes of a single dose. Longer-acting forms such as kisspeptin-54 and engineered analogs are being explored in research.

Human studies to date have generally reported it to be well tolerated in controlled research settings, with no major safety signals noted in the trials conducted so far. However, long-term safety, the effects of repeated use, and the quality of unregulated 'research' material are not established. Any decision about use belongs with a licensed clinician, not a website.

Does WikiPeps provide a kisspeptin dose?

No. There is no validated, approved human dose, and WikiPeps does not publish dosing protocols or amounts for any peptide. Dosing decisions are medical decisions that require a licensed clinician who can weigh your individual situation.

Hormones · Dosage

Kisspeptin dosage

Kisspeptin comes in 5 mg and 10 mg vials. Pick your vial to see exactly how much bacteriostatic water to add and how many insulin units to draw. Reconstitution math and unit conversions for the 5 mg and 10 mg vials. Human kisspeptin doses are weight-based reproductive-research doses; there is no validated consumer dose, so no usage range is shown.

5mg

At 2 mL water: 2.5 mg/mL
Per unit: 25 mcg

See the 5 mg card

10mg

At 2 mL water: 5 mg/mL
Per unit: 50 mcg

See the 10 mg card

Calculate for your vial

Enter the mg on your Kisspeptin vial, the bacteriostatic water you added, and your target dose — it works out the exact units to draw on a U-100 insulin syringe, for whatever you personally have.

Reconstitution Calculator

Units to draw (U-100)40units

Volume to draw0.4mL

Concentration2.5mg/mL

Per insulin unit25mcg

Doses per vial5doses

Check the decimal. A misplaced decimal point here is a 10× dosing error. Re-read every number, and confirm your dose with a licensed clinician before you draw.

Educational only — not a dosing recommendation. This tool does the measurement math; it does not tell you what to take. On a U-100 insulin syringe, 100 units = 1 mL.

Reconstitution figures are deterministic measurement math. WikiPeps is a community reference and sells injection supplies only — never peptides. Nothing here is medical advice.