KPV is a tripeptide made of three amino acids: lysine (K), proline (P), and valine (V). The sequence corresponds to the last three residues (11-13) of alpha-melanocyte-stimulating hormone (alpha-MSH). It has been studied mainly in cells and animals for anti-inflammatory activity. It is a research chemical and has not been approved as a medicine.

What is KPV studied for?

Most published KPV research is preclinical (cells and animals) and focuses on inflammation, particularly in models of inflammatory bowel disease and skin inflammation, with some work on antimicrobial activity. These findings do not establish that KPV is safe or effective in humans.

No. KPV is not approved by the U.S. FDA for any use. It is sold only as a research chemical. Whether it may be used by compounding pharmacies under the FDA's 503A bulk drug substances process has been the subject of ongoing FDA review, but being reviewed or evaluated is not the same as being approved as a drug.

KPV is not an approved drug or dietary supplement in the United States, so it cannot legally be marketed for human consumption. Laws vary by country, and rules for research chemicals can change. Check local regulations and consult a licensed professional.

How is KPV thought to work?

In laboratory studies, KPV appears to dampen inflammatory signaling by interfering with pathways such as NF-kB and MAP kinase, lowering pro-inflammatory cytokines. Unlike full alpha-MSH, it is reported to act largely without binding melanocortin receptors, partly through the peptide transporter PepT1. These are research-stage mechanisms, not confirmed human effects.

What are the reported side effects of KPV?

Human safety data are very limited because rigorous human trials are lacking. Animal studies have generally reported good tolerability, but that does not establish a human safety profile. Product purity in the research-chemical market is also inconsistent. Anyone considering it should speak with a licensed clinician first.

How is KPV dosed in research settings?

Published animal studies use a range of doses and routes that do not translate directly to humans, and there is no established, validated human dose. This page does not provide dosing instructions; dosing decisions belong with a licensed clinician.

Calms inflammation · Dosage

KPV dosage

KPV comes in 5 mg and 10 mg vials. Pick your vial to see exactly how much bacteriostatic water to add and how many insulin units to draw. Reconstitution math and unit conversions for the 5 mg and 10 mg vials. KPV has no validated human dose; the usage pattern shown is community-reported and anecdotal.

5mg

At 3 mL water: 1.67 mg/mL
Per unit: 16.67 mcg

See the 5 mg card

10mg

At 3 mL water: 3.33 mg/mL
Per unit: 33.33 mcg

See the 10 mg card

Calculate for your vial

Enter the mg on your KPV vial, the bacteriostatic water you added, and your target dose — it works out the exact units to draw on a U-100 insulin syringe, for whatever you personally have.

Reconstitution Calculator

Units to draw (U-100)18units

Volume to draw0.18mL

Concentration1.67mg/mL

Per insulin unit16.7mcg

Doses per vial16.7doses

Check the decimal. A misplaced decimal point here is a 10× dosing error. Re-read every number, and confirm your dose with a licensed clinician before you draw.

Educational only — not a dosing recommendation. This tool does the measurement math; it does not tell you what to take. On a U-100 insulin syringe, 100 units = 1 mL.

Reconstitution figures are deterministic measurement math. WikiPeps is a community reference and sells injection supplies only — never peptides. Nothing here is medical advice.