What is Melanotan II?

Melanotan II (MT-II, MT2) is a synthetic cyclic peptide that mimics alpha-melanocyte-stimulating hormone (alpha-MSH). It activates melanocortin receptors and has been studied for darkening skin and for effects on sexual function. It is a research chemical, not an FDA-approved medicine, and has not been proven safe or effective for general use.

Is Melanotan II FDA-approved or legal?

No. Melanotan II is not approved by the FDA for any use. The FDA has issued warnings and warning letters about unapproved melanotan products, and agencies in the UK, Australia, and the EU have warned against them. Material sold 'for research use only' is not an approved medicine and is not a substitute for clinician-supervised care.

How does Melanotan II work?

Melanotan II is a non-selective agonist at melanocortin receptors. By activating the MC1 receptor on pigment cells (melanocytes), it can stimulate melanin production and skin darkening. Its activity at MC3 and MC4 receptors in the brain is thought to underlie reported effects on appetite and sexual arousal.

Is Melanotan II the same as bremelanotide (Vyleesi) or PT-141?

No, but they are related. Bremelanotide (brand name Vyleesi, PT-141) is a melanocortin agonist that was developed from melanotan II chemistry and is FDA-approved (2019) for a specific condition in some premenopausal women. Melanotan II itself is a different, unapproved research chemical, and the two are not interchangeable.

What are the side effects of Melanotan II?

Commonly reported effects include nausea, facial flushing, and appetite suppression, plus darkening of moles and freckles. Published case reports have described more serious events including rhabdomyolysis (muscle breakdown), renal infarction, posterior reversible encephalopathy syndrome, priapism, and melanoma diagnosed in users. Long-term safety is unknown.

Can Melanotan II cause skin cancer?

A direct causal link has not been established in controlled studies, but several case reports describe melanoma arising in moles during or shortly after melanotan use, and the drug can darken and change existing moles in ways that may mask the warning signs of skin cancer. This is a recognized concern raised by dermatologists and regulators.

Does WikiPeps provide a Melanotan II dose?

No. There is no validated, approved human dose, and WikiPeps does not publish dosing protocols or amounts for any peptide. Dosing is a medical decision that requires a licensed clinician who can weigh your individual situation and the known risks.

Skin color & sex drive · Dosage

Melanotan II dosage

Melanotan II comes in 10 mg vials. Pick your vial to see exactly how much bacteriostatic water to add and how many insulin units to draw. Reconstitution math and unit conversions for the 10 mg vial. Melanotan II is an unapproved research chemical regulators have warned against; it has no validated human dose and the figures shown are community-reported.

10mg

At 2 mL water: 5 mg/mL
Per unit: 50 mcg

See the 10 mg card

Calculate for your vial

Enter the mg on your Melanotan II vial, the bacteriostatic water you added, and your target dose — it works out the exact units to draw on a U-100 insulin syringe, for whatever you personally have.

Reconstitution Calculator

Units to draw (U-100)5units

Volume to draw0.05mL

Concentration5mg/mL

Per insulin unit50mcg

Doses per vial40doses

Check the decimal. A misplaced decimal point here is a 10× dosing error. Re-read every number, and confirm your dose with a licensed clinician before you draw.

Educational only — not a dosing recommendation. This tool does the measurement math; it does not tell you what to take. On a U-100 insulin syringe, 100 units = 1 mL.

Reconstitution figures are deterministic measurement math. WikiPeps is a community reference and sells injection supplies only — never peptides. Nothing here is medical advice.