Semaglutide is a GLP-1 (glucagon-like peptide-1) receptor agonist, a prescription medication that mimics a natural gut hormone to help regulate blood sugar and appetite. It is FDA-approved and sold under brand names Ozempic, Rybelsus, and Wegovy. It must be prescribed and supervised by a licensed clinician.

What is semaglutide used for?

Ozempic and Rybelsus are FDA-approved to improve blood sugar in adults with type 2 diabetes (Ozempic also for reducing cardiovascular risk in certain patients). Wegovy is approved for chronic weight management in eligible adults and adolescents. Uses and eligibility are determined by a prescribing clinician.

Is semaglutide the same as Ozempic and Wegovy?

Yes — semaglutide is the active ingredient in all three. Ozempic and Rybelsus are approved for type 2 diabetes, and Wegovy is approved for weight management. They differ in dosing and approved indication, which is why a clinician matches the right product to the right patient.

Is semaglutide FDA-approved?

Yes. Unlike many research peptides, semaglutide is FDA-approved and is a prescription medication. It should only be obtained through a licensed pharmacy with a valid prescription and used under medical supervision.

What are the common side effects of semaglutide?

Commonly reported side effects include nausea, vomiting, diarrhea, constipation, and abdominal discomfort, especially when starting or increasing the dose. Serious risks are described in the prescribing information, including a boxed warning about thyroid C-cell tumors seen in rodents. A prescribing clinician reviews these risks for each patient.

How is semaglutide administered?

Injectable semaglutide (Ozempic, Wegovy) comes in a manufacturer prefilled pen for once-weekly subcutaneous injection, and Rybelsus is a daily oral tablet. Patients are trained by their clinician or pharmacist; this page describes the products factually and is not self-administration instruction.

Why does WikiPeps cover a prescription drug?

Because semaglutide is one of the most discussed peptide-based medications, and accurate, non-promotional education helps people ask their clinician the right questions. WikiPeps does not sell semaglutide and does not provide dosing or sourcing guidance for prescription drugs.

Prescription weight-loss med · Dosage

Semaglutide dosage

Semaglutide comes in 10 mg and 20 mg vials. Pick your vial to see exactly how much bacteriostatic water to add and how many insulin units to draw. Semaglutide is the prescription drug Ozempic/Wegovy/Rybelsus, dosed once weekly per its FDA label (titrated to 2.0–2.4 mg). The approved product is a metered pen with no reconstitution; the math here is for research vials only.

10mg

At 2 mL water: 5 mg/mL
Per unit: 50 mcg

See the 10 mg card

20mg

At 2 mL water: 10 mg/mL
Per unit: 100 mcg

See the 20 mg card

Calculate for your vial

Enter the mg on your Semaglutide vial, the bacteriostatic water you added, and your target dose — it works out the exact units to draw on a U-100 insulin syringe, for whatever you personally have.

Reconstitution Calculator

Units to draw (U-100)10units

Volume to draw0.1mL

Concentration5mg/mL

Per insulin unit50mcg

Doses per vial20doses

Check the decimal. A misplaced decimal point here is a 10× dosing error. Re-read every number, and confirm your dose with a licensed clinician before you draw.

Educational only — not a dosing recommendation. This tool does the measurement math; it does not tell you what to take. On a U-100 insulin syringe, 100 units = 1 mL.

Dosing schedule

Semaglutide · fixed weekly step-up schedule

Optional

A fixed weekly titration ladder. Body weight and goal are context, not a formula — people with more to lose more often climb toward the 2.4 mg maintenance dose.

10.25 mg/wkWeeks 1–4Starting dose
20.5 mg/wkWeeks 5–8
31.0 mg/wkWeeks 9–12
41.7 mg/wkWeeks 13–16
52.4 mg/wkWeek 17+Maintenance / max

Everyone starts at 0.25 mg and steps up every 4 weeks on the same schedule — the ladder is not calculated from body weight. Someone with more to lose more often titrates toward the 2.4 mg maintenance dose, while a lighter person losing well with few side effects may hold at a lower step. The dose is individualized by tolerability and response under medical supervision, not from your weight.

Source: FDA label — Wegovy® (semaglutide). Educational only — not medical advice and not a dosing recommendation. Any dosing decision belongs with a licensed clinician.

Reconstitution figures are deterministic measurement math. WikiPeps is a community reference and sells injection supplies only — never peptides. Nothing here is medical advice.