NAD+ (nicotinamide adenine dinucleotide) is a coenzyme found in every living cell. It is not a foreign drug — your body makes it from vitamin B3 forms and from precursors like nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN). It is central to how cells turn food into energy and repair DNA.

What is NAD+ studied for?

Research interest focuses on aging, metabolic health, mitochondrial function, and exercise adaptation, because tissue NAD+ levels appear to fall with age. Most human work has tested oral precursors (NR, NMN) rather than NAD+ itself, and reviewers describe the clinical benefits to date as modest and not firmly established.

Is NAD+ FDA-approved?

No. NAD+ is not an FDA-approved drug for anti-aging, energy, addiction recovery, or athletic performance. IV NAD+ infusions and injectable NAD+ are offered by wellness clinics under off-label or 'integrative' frameworks, and research-grade NAD+ is sold 'for research use only.' None of these are FDA-approved products for those uses.

Do oral NAD+ precursors actually raise NAD+ levels?

Human trials show that oral precursors such as nicotinamide riboside and nicotinamide mononucleotide can raise blood NAD+ levels, often roughly doubling them after about two weeks in some studies. Whether that translates into meaningful clinical benefits in healthy people is still uncertain, and several reviewers caution that effects have been overstated.

What are the risks of IV or injectable NAD+?

Reported IV NAD+ side effects include nausea, flushing, lightheadedness, headache, chest pressure, and muscle cramps, which are often tied to fast infusion rates. Any injection also carries risks of infection or reactions, and unregulated research-grade products may be contaminated or mislabeled. Talk to a licensed clinician before considering it.

Is NAD+ legal, and is it allowed for athletes?

NAD+ itself is not a controlled substance and is not named on the 2026 WADA Prohibited List. However, anti-doping experts note that WADA's S0 category covers non-approved substances, and WADA's IV-infusion limits can be exceeded by typical NAD+ drip volumes. Athletes should verify current rules and use strict liability caution.

How is research-grade NAD+ stored and prepared?

It usually ships as a lyophilized powder that must be kept cold and reconstituted with a sterile diluent before any laboratory use. WikiPeps describes the general handling process for education only and does not publish human dosing protocols or amounts.

Aging & metabolism · Dosage

NAD+ dosage

NAD+ comes in 250 mg and 500 mg vials. Pick your vial to see exactly how much bacteriostatic water to add and how many insulin units to draw. Reconstitution math and unit conversions for the 250 mg and 500 mg vials. NAD+ is a coenzyme, not an approved drug; clinic use is mainly slow IV infusion and there is no validated dose — figures shown are community-reported.

250mg

At 5 mL water: 50 mg/mL
Per unit: 500 mcg

See the 250 mg card

500mg

At 5 mL water: 100 mg/mL
Per unit: 1000 mcg

See the 500 mg card

Calculate for your vial

Enter the mg on your NAD+ vial, the bacteriostatic water you added, and your target dose — it works out the exact units to draw on a U-100 insulin syringe, for whatever you personally have.

Reconstitution Calculator

Units to draw (U-100)50units

Volume to draw0.5mL

Concentration50mg/mL

Per insulin unit500mcg

Doses per vial10doses

Check the decimal. A misplaced decimal point here is a 10× dosing error. Re-read every number, and confirm your dose with a licensed clinician before you draw.

Educational only — not a dosing recommendation. This tool does the measurement math; it does not tell you what to take. On a U-100 insulin syringe, 100 units = 1 mL.

Reconstitution figures are deterministic measurement math. WikiPeps is a community reference and sells injection supplies only — never peptides. Nothing here is medical advice.